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On March 14th celebrate `\pi` Day. Hug `\pi`—find a way to do it.
For those who favour `\tau=2\pi` will have to postpone celebrations until July 26th. That's what you get for thinking that `\pi` is wrong. I sympathize with this position and have `\tau` day art too!
If you're not into details, you may opt to party on July 22nd, which is `\pi` approximation day (`\pi` ≈ 22/7). It's 20% more accurate that the official `\pi` day!
Finally, if you believe that `\pi = 3`, you should read why `\pi` is not equal to 3.
Caelum non animum mutant qui trans mare currunt.
—Horace
This year: creatures that don't exist, but once did, in the skies.
This year's `\pi` day song is Exploration by Karminsky Experience Inc. Why? Because "you never know what you'll find on an exploration".
Want to contribute to the mythology behind the constellations in the `\pi` in the sky? Many already have a story, but others still need one. Please submit your stories!
This year I wanted to something more than visuals. Space is vast, so let's fill it with words.
I asked my good friend and poet, Paolo Marcazzan, to collaborate. I described the idea for the art—a universe of stars based on `\pi` and the extinct creatures that live within it—and asked him to find the matching words.
And they could not have been more perfect.
The poem situates the dark as a place for contention and ongoing confrontation. Whether in the recesses of space or heart, the poem probes the territory of distance, absence, uncertainty and muteness. It considers the relational as default positioning of existence (earthly, universal), and that which remains unmet within that context.
Life in its dimension of cross-grained, often broken linearity is juxtaposed with a quote form Dante that references instead his vision of sidereal circularity as the benign force that moves all things in the universe. For the earthbound, the questions and concerns remain those of identity, passage, escape from transiency, and slow tempering of hope.
A short electronic music concert based on structures of chromosomes 21, Y and 1.
Each track uses a microtonal scale derived from the cytogenetic band positions of the chromosome. Rhythms are based on relative lengths of cytogenetic bands.
Either I've been missing something or nothing has been going on. —Karen Elizabeth Gordon
Missing data are everywhere. Subjects may decline to participate in a survey or fail to answer sensitive questions. A cell culture might fail due to contamination. Instrument failures or mishandling of a sample may lead to missing observations. But why are missing data a problem?
This month, we begin a series of articles about practical and statistical aspects of missing data. We'll see that missing data can increase variability and introduce bias and we will ask whether anything can be done to mitigate these consequences. It turns out that, in the case where we know nothing about the missing subjects, no mitigation is possible. We must accept higher variability and, if we have a suspicion that the missing subjects aren’t completely random, possible bias as well.
Tanujit Dey, T., Lipsitz, S.R., Fitzmaurice, G., Krzywinski, M. & Altman, N. (2026) Points of significance: Consequences of missing data. Nat. Methods 23:1661–1663.
It is not certain that everything is uncertain. —Blaise Pascal
We have already explored how we can mitigate bias caused by confounding variables in observational studies using propensity score (PS) matching (PSM) and propensity score weighting (PSW). However, any statistical model is only as good as its assumptions and, if it is specified incorrectly, it can itself produce biased estimates of the treatment effect.
This month, we explore double robustness, a powerful statistical concept that provides a valuable “safety net” against the risk of an incorrect model. It offers two opportunities, instead of just one, to obtain a valid estimate of the treatment effect — making it possible to draw credible causal inferences from observational data without having to depend on a single set of modeling assumptions.
Kurz, C.F., Krzywinski, M. & Altman, N. (2026) Points of significance: Double Robustness. Nat. Methods 23:868–869.
My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.
Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.
Browse my gallery of cover designs.
Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.
Go ahead, see what you can't see.
Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.
I also provide the position, size, and color of each circle on each test plate.