Moon above
All the secrets I've told
When we're alone
Down here
I'm always lonely
When you're gone
— Down Here / Moon Above, Flunk (History of Everything Ever)
Why don't we send this music to space? What do you say?
Flunk has always had a special place in my heart. When I became involved in the Sanctuary Project — a kind of love letter to the Universe — I saw a way to say thank you to by favourite band.
So I invited them to come with me to somewhere distant and cold.
The Sanctuary Project is a Lunar vault for humanity, inspired by projects like the Golden Record and engraved on ten 10 cm sapphire discs. The discs include math, science, maps, poetry, art and a couple of jokes.
Oh, and a backup of our species. Push to reboot.
A couple of years ago, I reached out to Ulf Nygaard, the principal and founder of Flunk, and invited him to contribute a song to Sanctuary. Something that would sound great on the Moon.
“I'll make something perfect”, he said.
And then he did.
I sat down for drinks with Flunk in Oslo. We celebrated Hitchmas. Make it a double — we were going to go to the Moon.
“Ulf, why is this album called Chemistry and Math?” I asked about Flunk's latest album at the time. And perhaps one with the most unusual title.
I will never forget his answer.
“Sitting in a cafe, I saw two people crossing the street from opposite sides. As they passed each other in the middle, they recognized each other and started talking.”
“In the end, it's just chemistry and math.”
To me, this was the Mariana trench of deep romantic statments. I knew then Flunk was the perfect match for this project.
Ok, I knew thew before too.
On May 28th, Flunk released their new album History of Everything Every and Track 1 is Down Here / Moon Above.
While the original plan was for the song to make it to the Moon before its debut on Earth, this didn't quite happen. We're still working on the Moon angle.
Yes, I do science and make art and I love Flunk, but what does all this have to do with me.
Well, four of the Sanctuary discs contain the backup for humanity: fully sequenced genomes of a woman and man. The individuals were randomly and anonymously selected from our Healthy Aging Study lead by Dr. Angela Brooks-Wilson. The DNA was sequenced at Canada's Michael Smith Genome Sciences Center.
I designed and created the content for these discs, which not only include the genomes but also the proteome (gene protein sequences) and the chemical structures of associated metabolites. The genomes include about 10 million SNPs to represent all our variation (imagine me waving my hands around at this point). The SNPs are encoded inline with the sequence, so you do not actually know what the original sequenced genome was — at each position of variation you have a choice of bases.
The discs also contain art and snippes of culture (some pop and some not). It's basically a giant cosmic Easter egg.
Each disc is a 10 cm diameter sapphire wafer containing 3 billion 1-bit pixels.
They're thermodynamically inert and will last forever. Roughly speaking.
You can pixel-peep and browse each of the discs.
To me, these discs are a love poem to the Universe. Or a post card — I love post cards.
The four genome discs look like this.
You know you're done reading when you get to the end.
The first disc, which contains roughly the first half of the female genome, also contains instructions for decoding, along with a few of our learned lessons (Nuremberg Code and Declaration of Helsinki) that remind the reader not to experiment carelessly with the information.
Peeping a bit closer, these instructions take shape. the long black strip is a spectrogram encoding of Flunk's song. For a closeup of the decoding instructions for the discs, see the Instructions section.
Flunk's song is encoded using 128 mel 3-bit spectrogram. This takes 11,688 × 384 1-bit pixels on the discs. For details see the Sonogram section.
A 512 mel 1-bit encoding of the full History of Everything Ever album. Great for your wall or Moon patch.
Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.
Go ahead, see what you can't see.
Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.
I also provide the position, size, and color of each circle on each test plate.
What immortal hand or eye, could frame thy fearful symmetry? — William Blake, "The Tyger"
This month, we look at symmetric regression, which, unlike simple linear regression, it is reversible — remaining unaltered when the variables are swapped.
Simple linear regression can summarize the linear relationship between two variables `X` and `Y` — for example, when `Y` is considered the response (dependent) and `X` the predictor (independent) variable.
However, there are times when we are not interested (or able) to distinguish between dependent and independent variables — either because they have the same importance or the same role. This is where symmetric regression can help.
Luca Greco, George Luta, Martin Krzywinski & Naomi Altman (2025) Points of significance: Symmetric alternatives to the ordinary least squares regression. Nat. Methods 22:1610–1612.
Fuelled by philanthropy, findings into the workings of BRCA1 and BRCA2 genes have led to groundbreaking research and lifesaving innovations to care for families facing cancer.
This set of 100 one-of-a-kind prints explore the structure of these genes. Each artwork is unique — if you put them all together, you get the full sequence of the BRCA1 and BRCA2 proteins.
The needs of the many outweigh the needs of the few. —Mr. Spock (Star Trek II)
This month, we explore a related and powerful technique to address bias: propensity score weighting (PSW), which applies weights to each subject instead of matching (or discarding) them.
Kurz, C.F., Krzywinski, M. & Altman, N. (2025) Points of significance: Propensity score weighting. Nat. Methods 22:638–640.
Celebrate π Day (March 14th) and sequence digits like its 1999. Let's call some peaks.