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And whatever I do will become forever what I've done.Wislawa Szymborskadon't rehearsemore quotes
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fun + Amusement
Do you know the difference between corn and a dinosaur? It might appear that the makers of Jurassic World don't care whether you do. Or don't know whether you care.
Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
DUMB. DUMMER | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.

Dummer — Like Nothing Else

This project might give you the impression that I don't like Hummers. You'd be right. It was picked up by the New York Times Laugh Lines in 2008.

I've since made a few updates, to include the 2024 Hummer EV SUV.

The Hummer font is a slightly modified Antique Olive Nord. The Like Nothing Else tag line is Trade Gothic. Both have character widths increased to 110-120% and individually adjusted kerning.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Hummer logo. (EPS, PNG, AI)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer logo. (EPS, PNG)

2 · The Hummer parodies

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
TRULY LIKE NOTHING ELSE. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
DUMB. DUMMER | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
GET ROOM TO GROW. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
THE ENVIRONMENT. F*CK IT. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
DRIVE. EVERYWHERE. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
HAVE THE BIGGEST. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.

3 · The Obnoxious is electric

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
12.5 MORE INCHES. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
EVERYONE WILL NOTICE. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
DOES THIS CAR MAKE ME LOOK BIG? | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
THE BEST TOYS RUN ON BATTERIES. | Dummer. Like nothing else. A parody of the GMC line of Hummer SUVs.
Will the egg survive? Learn about the results of the UBC Rocket Challenge.

4 · Reception

4.1 · Rants

It delights me that this project produced my first hate mail.

I want to meet Doug and give him a hug for adding another dimension to this project.

4.2 · Raves

The images got picked up by the New York Times laughlines blog, which drew a couple of fan mails.

But neither made me feel as good as Doug's email.

news + thoughts

Happy 2025 π Day—
TTCAGT: a sequence of digits

Thu 13-03-2025

Celebrate π Day (March 14th) and sequence digits like its 1999. Let's call some peaks.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2025 π DAY | TTCAGT: a sequence of digits. The digits of π are encoded into DNA sequence and visualized with Sanger sequencing. (details)

Crafting 10 Years of Statistics Explanations: Points of Significance

Sun 09-03-2025

I don’t have good luck in the match points. —Rafael Nadal, Spanish tennis player

Points of Significance is an ongoing series of short articles about statistics in Nature Methods that started in 2013. Its aim is to provide clear explanations of essential concepts in statistics for a nonspecialist audience. The articles favor heuristic explanations and make extensive use of simulated examples and graphical explanations, while maintaining mathematical rigor.

Topics range from basic, but often misunderstood, such as uncertainty and P-values, to relatively advanced, but often neglected, such as the error-in-variables problem and the curse of dimensionality. More recent articles have focused on timely topics such as modeling of epidemics, machine learning, and neural networks.

In this article, we discuss the evolution of topics and details behind some of the story arcs, our approach to crafting statistical explanations and narratives, and our use of figures and numerical simulations as props for building understanding.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Crafting 10 Years of Statistics Explanations: Points of Significance. (read)

Altman, N. & Krzywinski, M. (2025) Crafting 10 Years of Statistics Explanations: Points of Significance. Annual Review of Statistics and Its Application 12:69–87.

Propensity score matching

Mon 16-09-2024

I don’t have good luck in the match points. —Rafael Nadal, Spanish tennis player

In many experimental designs, we need to keep in mind the possibility of confounding variables, which may give rise to bias in the estimate of the treatment effect.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Propensity score matching. (read)

If the control and experimental groups aren't matched (or, roughly, similar enough), this bias can arise.

Sometimes this can be dealt with by randomizing, which on average can balance this effect out. When randomization is not possible, propensity score matching is an excellent strategy to match control and experimental groups.

Kurz, C.F., Krzywinski, M. & Altman, N. (2024) Points of significance: Propensity score matching. Nat. Methods 21:1770–1772.

Understanding p-values and significance

Tue 24-09-2024

P-values combined with estimates of effect size are used to assess the importance of experimental results. However, their interpretation can be invalidated by selection bias when testing multiple hypotheses, fitting multiple models or even informally selecting results that seem interesting after observing the data.

We offer an introduction to principled uses of p-values (targeted at the non-specialist) and identify questionable practices to be avoided.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Understanding p-values and significance. (read)

Altman, N. & Krzywinski, M. (2024) Understanding p-values and significance. Laboratory Animals 58:443–446.

Depicting variability and uncertainty using intervals and error bars

Thu 05-09-2024

Variability is inherent in most biological systems due to differences among members of the population. Two types of variation are commonly observed in studies: differences among samples and the “error” in estimating a population parameter (e.g. mean) from a sample. While these concepts are fundamentally very different, the associated variation is often expressed using similar notation—an interval that represents a range of values with a lower and upper bound.

In this article we discuss how common intervals are used (and misused).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Depicting variability and uncertainty using intervals and error bars. (read)

Altman, N. & Krzywinski, M. (2024) Depicting variability and uncertainty using intervals and error bars. Laboratory Animals 58:453–456.

Nasa to send our human genome discs to the Moon

Sat 23-03-2024

We'd like to say a ‘cosmic hello’: mathematics, culture, palaeontology, art and science, and ... human genomes.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
SANCTUARY PROJECT | A cosmic hello of art, science, and genomes. (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
SANCTUARY PROJECT | Benoit Faiveley, founder of the Sanctuary project gives the Sanctuary disc a visual check at CEA LeQ Grenoble (image: Vincent Thomas). (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
SANCTUARY PROJECT | Sanctuary team examines the Life disc at INRIA Paris Saclay (image: Benedict Redgrove) (details)
Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA
Google whack “vicissitudinal corporealization”
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