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yes + no

Yes or No

Always just answers

Your answer is
maybe
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
homer
aaaw, come on!
This answer is 5.8 days old.
I want another answer Whenever you're ready.

1 · We have answers for you

Do you want free answers to your problems presented in a clear and concise manner? Read on.

It doesn't matter whether you're arguing with your partner, friend, pet, or yourself. We can help.

Simply put: we provide answers to your problems.

How do we do it? Through our insightful knowledge of

  • different types of problems
  • different types of answers
  • linear congruent method

we can confidently present an answer to your questions. It's hard to believe, I know!

The best part? Well, other than the right answers, of course. Our service is free! We provide answers at absolutely no charge. We don't want your money — we want you on your way with an answer in hand.

1.1 · What can I expect?

Why, answers of course. Your answer will appear in the following form

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

The correct course of action (YES, NO or MAYBE) will be presented one of many style.

1.2 · Can I trust the answer

We're confident that our answers are 100% correct.

Just read this testimonial — others have already been answered. You can be be next!

I got the answer in the style of Homer Simpson. I just couldn't stop giggling. Thanks for brightening up my day.
—Susan W

1.3 · I'm ready for the answer

Be prepared, though. Using our service may lead you down the correct road quickly, efficiently and with time to spare. You may be surprised.

When you're ready, focus on the question you want to have solved and hit the I WANT AN ANSWER button above.

1.4 · I already got an answer

Congratulations! Use it well.

Our records show that you have already received an answer of MAYBE, which is 5.8 days old.

This answer is stale — answers are good for only 5 minutes.

Never use a stale answer. Instead, consider getting a new answer — but make sure you first have a problem. Answers without problems cannot be retroactively applied.

1.5 · I need more answers

Don't we all. You can obtain an answer every 5 minutes.

Even if it feels like you can't wait — you can.

2 · Our method

Finding answers to your problems — that's what we do.

It's not easy, especially when you consider the variety of problems we deal with.

That's why we use the linear congruent method in computing answers. Without burdening you with technicalities (those mathematicians sure like to make things sound complicated!), we have selected this method because

  • the linear congruent method scales favourably with the number of problems — we can answer many problems without investing in expensive hardware
  • “linear” is a common synonym for “straight”. We give you the straight answer.
  • it is “congruent”, meaning that it corresponds to the right answer.

3 · Our service

We provide answers to you free of charge. Our rewards come from solving your problems — every time.

So far, we have generated 1,162 answers. Each one as correct as the next.

Below is a sample answer. Do not use this answer to solve a problem. If you want a real answer, hit the I WANT AN ANSWER button above.

news + thoughts

Nature Biotechnology cover

Thu 23-04-2026

My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.

Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Nature Biotechnology phylogenetic tree cover (volume 44, issue 4, 7 April 2026). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Happy 2026 π Day—
Art for the 5%

Fri 13-03-2026

Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.

Go ahead, see what you can't see.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2026 π DAY | Art for the 5%. Shown in the style of Ishihara color test plates, the art is visible only to those with colour blindness. (details)

Ishihara's Tests for Colour Deficiency

Sun 08-03-2026

Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.

I also provide the position, size, and color of each circle on each test plate.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
ISHIHARA'S TEST PLATE 6 | This plate is part of the set of transformation plates. If you see 5, you're ok. If you see 2, you're not. (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
ISHIHARA'S TEST PLATE 18 | This plate is part of the set of mysterious hidden plates. If you don't see anything, you're ok. If you see 5, you're not. (details)

Symmetric alternatives to the ordinary least squares regression

Wed 23-07-2025

What immortal hand or eye, could frame thy fearful symmetry? — William Blake, "The Tyger"

This month, we look at symmetric regression, which, unlike simple linear regression, it is reversible — remaining unaltered when the variables are swapped.

Simple linear regression can summarize the linear relationship between two variables `X` and `Y` — for example, when `Y` is considered the response (dependent) and `X` the predictor (independent) variable.

However, there are times when we are not interested (or able) to distinguish between dependent and independent variables — either because they have the same importance or the same role. This is where symmetric regression can help.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Symmetric alternatives to the ordinary least squares regression. Geometry of quantities minimized in OLS and symmetric regression. OLS minimizes `\Sigma e_y^2` in `Y` ~ `X` and `\Sigma e_x^2` `X` ~ `Y`. Pythagorean regression minimizes AB (magenta). Geometric means regression (GMR) minimizes area of ABP (orange). Orthogonal regression (OR) minimizes HP (blue). (read)

Luca Greco, George Luta, Martin Krzywinski & Naomi Altman (2025) Points of significance: Symmetric alternatives to the ordinary least squares regression. Nat. Methods 22:1610–1612.

Beyond Belief Campaign BRCA Art

Wed 11-06-2025

Fuelled by philanthropy, findings into the workings of BRCA1 and BRCA2 genes have led to groundbreaking research and lifesaving innovations to care for families facing cancer.

This set of 100 one-of-a-kind prints explore the structure of these genes. Each artwork is unique — if you put them all together, you get the full sequence of the BRCA1 and BRCA2 proteins.

Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentrePHSA
Google whack “vicissitudinal corporealization”
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