Yes or No
Always just answers
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Do you want free answers to your problems presented in a clear and concise manner? Read on.
It doesn't matter whether you're arguing with your partner, friend, pet, or yourself. We can help.
Simply put: we provide answers to your problems.
How do we do it? Through our insightful knowledge of
- different types of problems
- different types of answers
- linear congruent method
we can confidently present an answer to your questions. It's hard to believe, I know!
The best part? Well, other than the right answers, of course. Our service is free! We provide answers at absolutely no charge. We don't want your money — we want you on your way with an answer in hand.
Why, answers of course. Your answer will appear in the following form
The correct course of action (YES, NO or MAYBE) will be presented one of many style.
We're confident that our answers are 100% correct.
Just read this testimonial — others have already been answered. You can be be next!
Thank you! You make decision making so simple. I didn't actually realize that there were only three choices. I wish I knew about this service last week...
—Lesa B
Be prepared, though. Using our service may lead you down the correct road quickly, efficiently and with time to spare. You may be surprised.
When you're ready, focus on the question you want to have solved and hit the I WANT AN ANSWER button above.
Congratulations! Use it well.
Our records show that you have already received an answer of NO, which is 10.7 hours old.
This answer is stale — answers are good for only 5 minutes.
Never use a stale answer. Instead, consider getting a new answer — but make sure you first have a problem. Answers without problems cannot be retroactively applied.
Don't we all. You can obtain an answer every 5 minutes.
Even if it feels like you can't wait — you can.
Finding answers to your problems — that's what we do.
It's not easy, especially when you consider the variety of problems we deal with.
That's why we use the linear congruent method in computing answers. Without burdening you with technicalities (those mathematicians sure like to make things sound complicated!), we have selected this method because
- the linear congruent method scales favourably with the number of problems — we can answer many problems without investing in expensive hardware
- “linear” is a common synonym for “straight”. We give you the straight answer.
- it is “congruent”, meaning that it corresponds to the right answer.
We provide answers to you free of charge. Our rewards come from solving your problems — every time.
So far, we have generated 1,241 answers. Each one as correct as the next.
Below is a sample answer. Do not use this answer to solve a problem. If you want a real answer, hit the I WANT AN ANSWER button above.
Consequences of missing data
Either I've been missing something or nothing has been going on. —Karen Elizabeth Gordon
Missing data are everywhere. Subjects may decline to participate in a survey or fail to answer sensitive questions. A cell culture might fail due to contamination. Instrument failures or mishandling of a sample may lead to missing observations. But why are missing data a problem?
This month, we begin a series of articles about practical and statistical aspects of missing data. We'll see that missing data can increase variability and introduce bias and we will ask whether anything can be done to mitigate these consequences. It turns out that, in the case where we know nothing about the missing subjects, no mitigation is possible. We must accept higher variability and, if we have a suspicion that the missing subjects aren’t completely random, possible bias as well.
Tanujit Dey, T., Lipsitz, S.R., Fitzmaurice, G., Krzywinski, M. & Altman, N. (2026) Points of significance: Consequences of missing data. Nat. Methods 23:1661–1663.
Double Robustness
It is not certain that everything is uncertain. —Blaise Pascal
We have already explored how we can mitigate bias caused by confounding variables in observational studies using propensity score (PS) matching (PSM) and propensity score weighting (PSW). However, any statistical model is only as good as its assumptions and, if it is specified incorrectly, it can itself produce biased estimates of the treatment effect.
This month, we explore double robustness, a powerful statistical concept that provides a valuable “safety net” against the risk of an incorrect model. It offers two opportunities, instead of just one, to obtain a valid estimate of the treatment effect — making it possible to draw credible causal inferences from observational data without having to depend on a single set of modeling assumptions.
Kurz, C.F., Krzywinski, M. & Altman, N. (2026) Points of significance: Double Robustness. Nat. Methods 23:868–869.
Nature Biotechnology cover
My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.
Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.
Browse my gallery of cover designs.
Happy 2026 π Day—
Art for the 5%
Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.
Go ahead, see what you can't see.
Ishihara's Tests for Colour Deficiency
Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.
I also provide the position, size, and color of each circle on each test plate.
