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A method for ASCII art that uses a variety of weights of proportionally-spaced fonts. Images can be rendered using characters that best match the local features of the image or using specific text."

The Ptolemaic Clock — A Proposal

1 · The standard clock

Consider the lowly wall clock. It's practical and generally tells the correct time. It's the same clock everywhere and after a while it gets boring pretty quickly—maybe now?

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
In a standard clock, the bezel is fixed and the hands rotate.

In the regular clock the face bezels stay in place and the hands move. Why am I telling you this? Well, maybe you see where I'm going.

2 · The Ptolemaic clock

Who says it's the hands that have to rotate? Instead of rotating hands and a stationary bezel, consider the clock with stationary hands rotating bezels.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
In the Ptolemaic clock, the hands stay in place while independent minute and hour hand bezels rotate to simulate the movement of the hands.

In the Ptolemaic clock there are two independent bezels and two independent hands. The bezels rotate counterclockwise to simulate the standard clockwise motion of the hands. The hands are not moving but in the frame of reference of the bezels, it's the hands that are rotating. The position of the bezel is always related to the current time and the position of its corresponding hand.

The bezel can move clockwise.

Thanks to Rodrigo Goya for suggesting the name for this kind of clock—Ptolemaic Clock, named so after the geocentric Ptolemaic model of the solar system.

3 · Telling time on the Ptolemaic clock

To tell the time on the Ptolemaic clock is a process identical to using the standard clock. You look at the bezel numbers at the ends of the hour and minute hands.

On the fixed bezel layout, most people will take a short cut and tell the time by the position of the hands. This works as long as you have a standard clock. On a Ptolemaic clock the position of the hands tells you nothing.

Here is a Ptolemaic clock telling us it is 6:30. It uses the same position of hands as in the figures above.

You know this because the blue hour hand points to midway between 6 and 7 on the inner hour bezel and the grey minute hand points to 30 on the outer minute bezel.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
It is 6:30 on this Ptolemaic clock.

After 15 minutes, it's 6:45 and our Ptolemaic clock bezels have moved a little bit.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
It is 6:45 on this Ptolemaic clock.

Can you tell what time it is on the Ptolemaic clock below?

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
If you answered 8:50, you are correct. It is 8:50.

4 · Customizing the Ptolemaic clock

Customizing your Ptolemaic clock is easy. Simply adjust the hands to desired positions and set the time by moving the bezels. The clock below shows the same time as the clock in the above figure — both show 8:50.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
This clock tells us it's 8:50. Compare this to the clock in the figure above, which also tells the same time.

5 · Ptolemaic clock — Hard layout

In the clock design shown here, the hands are the same size and only differ by color. To make things less confusing, emphasize the hour hand.

To make things more confusing, remove all color and number cues, keeping only a single symbol on each of the bezels to indicate 12 o'clock and 0 minutes. This is shown in the clock below.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
In the hard layout of a Ptolemaic clock, there are fewer cues. I think it's 8:50.

6 · Ptolemaic clock — Newsroom parodies

Spice it up with multiple Ptolemaic clocks side-by-side telling the same time with different hand positions.

Suppose it is 2:30 in Vancouver—this is my location. The clocks below all show 2:30, but with hands set to 5:30, 11:30 and 7:30.

Non-standard clock with rotating bezel. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Looks like a wall of clocks in a newsroom. Except these Ptolemaic clocks tell us that it's 2:30, three times over in Vancouver.

These hand positions are those that would appear on a standard clock showing the times in New York (5:30), Paris (11:30) and Tokyo (7:30).

Let's now use the Ptolemaic clock to show times at these three locations but with the hand set to the curiously satisfying layout of 10ish minutes to 2.

Non-standard clock with rotating bezel. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A challenging panel of Ptolemaic clocks.

6.1 · Variation 1

Set both hand positions to 12 o'clock and then remove the hands; to tell time, read the numbers on the hour and minute bezels at the apex of the clock.

6.2 · Variation 2

Sophisticated implementations of the Ptolemaic clock could periodically randomize hand positions to keep things interesting; by the time you've figured out the time in the morning, you're wide awake.

Every minute the clock randomly resets its hand positions. The movement is smooth and the bezels follow.

7 · Hardware implementation

If you would like to implement the Ptolemaic clock, I would be happy to hear from you. One should be able to take a regular wall clock, reverse the direction of the hand mechanism and rig a freely moving bezel to each of the minute and hour mechanism. The hands should not move and can be fixed to the front glass plate, for example.

7.1 · 3D printed Ptolemaic clock

Someone made templates for 3D printing a Ptolemaic clock.

8 · Fun, right?

It should now be clear that the Ptolemaic clock is superior to the standard clock. The reasons are

  • it's much harder to tell time on the Ptolemaic clock, which makes your brain do more work
  • it tips its hat off to a simpler time when we didn't know anything and hints at the possibility of regression anytime
    • it will confuse everyone
    • you have a great excuse for being late
    • return to geocentric values!
  • you can customize your own Ptolemaic clock by moving the hands to arbitrary locations
    • two Ptolemaic clocks can have their hands and bezels at different positions but still be telling the same time
    • two Ptolemaic clocks can have their hands at the same position but be telling different times
news + thoughts

Nature Biotechnology cover

Thu 23-04-2026

My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.

Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Nature Biotechnology phylogenetic tree cover (volume 44, issue 4, 7 April 2026). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Happy 2026 π Day—
Art for the 5%

Fri 13-03-2026

Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.

Go ahead, see what you can't see.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2026 π DAY | Art for the 5%. Shown in the style of Ishihara color test plates, the art is visible only to those with colour blindness. (details)

Ishihara's Tests for Colour Deficiency

Sun 08-03-2026

Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.

I also provide the position, size, and color of each circle on each test plate.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
ISHIHARA'S TEST PLATE 6 | This plate is part of the set of transformation plates. If you see 5, you're ok. If you see 2, you're not. (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
ISHIHARA'S TEST PLATE 18 | This plate is part of the set of mysterious hidden plates. If you don't see anything, you're ok. If you see 5, you're not. (details)

Symmetric alternatives to the ordinary least squares regression

Wed 23-07-2025

What immortal hand or eye, could frame thy fearful symmetry? — William Blake, "The Tyger"

This month, we look at symmetric regression, which, unlike simple linear regression, it is reversible — remaining unaltered when the variables are swapped.

Simple linear regression can summarize the linear relationship between two variables `X` and `Y` — for example, when `Y` is considered the response (dependent) and `X` the predictor (independent) variable.

However, there are times when we are not interested (or able) to distinguish between dependent and independent variables — either because they have the same importance or the same role. This is where symmetric regression can help.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Symmetric alternatives to the ordinary least squares regression. Geometry of quantities minimized in OLS and symmetric regression. OLS minimizes `\Sigma e_y^2` in `Y` ~ `X` and `\Sigma e_x^2` `X` ~ `Y`. Pythagorean regression minimizes AB (magenta). Geometric means regression (GMR) minimizes area of ABP (orange). Orthogonal regression (OR) minimizes HP (blue). (read)

Luca Greco, George Luta, Martin Krzywinski & Naomi Altman (2025) Points of significance: Symmetric alternatives to the ordinary least squares regression. Nat. Methods 22:1610–1612.

Beyond Belief Campaign BRCA Art

Wed 11-06-2025

Fuelled by philanthropy, findings into the workings of BRCA1 and BRCA2 genes have led to groundbreaking research and lifesaving innovations to care for families facing cancer.

This set of 100 one-of-a-kind prints explore the structure of these genes. Each artwork is unique — if you put them all together, you get the full sequence of the BRCA1 and BRCA2 proteins.

Propensity score weighting

Mon 17-03-2025

The needs of the many outweigh the needs of the few. —Mr. Spock (Star Trek II)

This month, we explore a related and powerful technique to address bias: propensity score weighting (PSW), which applies weights to each subject instead of matching (or discarding) them.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Propensity score weighting. (read)

Kurz, C.F., Krzywinski, M. & Altman, N. (2025) Points of significance: Propensity score weighting. Nat. Methods 22:638–640.

Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentrePHSA
Google whack “vicissitudinal corporealization”
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