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Where am I supposed to go? Where was I supposed to know?Violet Indianaget lost in questionsmore quotes
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visualization + math

π Day 2025 Art Posters - TTCAGT: a sequence of digits
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
2025 π DAY | TTCAGT: A sequence of digits. 768 digits of `\pi` as a Sanger sequencing trace of 1,536 peaks. Decode the sequence (BUY ARTWORK)

`\pi` Day 2015 Art Posters


Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2024 π DAY | Explore the garden of digits.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2023 π DAY | Repeated sequence

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2022 π DAY | three one four: a number of digits

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2021 π DAY | Good things grow for those who wait.' edition.


Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2020 π DAY | The piku.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2019 π DAY | Hundreds of digits, hundreds of languages and a special kids' edition.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2018 π DAY | Street maps to new destinations.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2017 π DAY | Imagine the sky in a new way.


Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2016 π APPROXIMATION DAY | What would happen if about right was right.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2016 π DAY | These digits really fall for each other.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2015 π DAY | A transcendental experience.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2014 π APPROXIMATION DAY | Spirals into roughness.


Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2014 π DAY | Hypnotizes you into looking.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2014 π DAY | Come into the fold.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2013 π DAY | Where it started.

Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
CIRCULAR π ART | And other distractions.

On March 14th celebrate `\pi` Day. Hug `\pi`—find a way to do it.

For those who favour `\tau=2\pi` will have to postpone celebrations until July 26th. That's what you get for thinking that `\pi` is wrong. I sympathize with this position and have `\tau` day art too!

If you're not into details, you may opt to party on July 22nd, which is `\pi` approximation day (`\pi` ≈ 22/7). It's 20% more accurate that the official `\pi` day!

Finally, if you believe that `\pi = 3`, you should read why `\pi` is not equal to 3.

Most of the art is available for purchase as framed prints and, yes, even pillows. Sleep's never been more important — I take custom requests.

Not a circle in sight in the 2015 `\pi` day art. Try to figure out how up to 612,330 digits are encoded before reading about the method. `\pi`'s transcendental friends `\phi` and `e` are there too—golden and natural. Get it?

This year's `\pi` day is particularly special. The digits of time specify a precise time if the date is encoded in North American day-month-year convention: 3-14-15 9:26:53.

The art has been featured in Ana Swanson's Wonkblog article at the Washington Post—10 Stunning Images Show The Beauty Hidden in `\pi`.

I find this image deeply beautiful and deeply troubling, and I’ll try to explain why. —Max Cooper

The 7-level tree map was used for the Transcendental Tree Map track on Max Cooper's Yearning for the Infinite album. The album is an “audio/visual rendering with our obsession with the unobtainable”.

The video for the track was a collaboration between myself and Nick Cobby. The music contains layered loops whose lengths are based on prime numbers—as the track plays, some loops individually come in and out of phase with others, forming a longer loop. The full set never synchronizes though.

The transcendental tree map encodes the first 20,244 digits of `\pi` = 3.1415...7012.

“Transcendental Tree Map” live at the album's premiere at the Barbican Hall in London. Learn about the album.

creating the video

The video constructs and then chaotically deconstructs a 7 level tree map of the digits of `\pi`. This map is shown below and is similar to other images I made for 2015 Pi Day, except that here the map is formatted for a 16:9 screen.

The video starts with an explicit construction of the map. This process begins with dividing the canvas with 3 vertical lines, which forms 4 rectangles. Each of the four rectangles formed by this process is divided with 1, 4, 1 and 5 horizontal lines, respectively. This forms 2 + 5 + 2 + 6 = 15 rectangles. Each of the 15 rectangles is divided by vertical lines according to the next 15 digits of Pi. This process repeats until we have performed the loop 7 times.

The division of each rectangle is not even—the positions of the lines are slightly jittered. This gives the map a more organic feel.


Pi Day 2015 Art Posters
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
20,244 digits of `\pi` in a 7 level treemap. Variable line thickness. This is the image that was the basis for Max Cooper's Transcendental Area Map track on the Yearning for Infinity album. (zoom, BUY ARTWORK)

The number of digits encoded in each loop is 1, 4, 15, 98, 548, 2,962 and 16,616. In total, 17,180 vertical and 3,064 horizontal lines are drawn and these form the backbone of the map.

The video is created by layering numerous animations of the construction of the map, in which the rate and order of line growth is varied. Blinking rectangles indicate that the lines for a digit have completed drawing.

news + thoughts

Happy 2025 π Day—
TTCAGT: a sequence of digits

Thu 13-03-2025

Celebrate π Day (March 14th) and sequence digits like its 1999. Let's call some peaks.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2025 π DAY | TTCAGT: a sequence of digits. The digits of π are encoded into DNA sequence and visualized with Sanger sequencing. (details)

Crafting 10 Years of Statistics Explanations: Points of Significance

Sun 09-03-2025

I don’t have good luck in the match points. —Rafael Nadal, Spanish tennis player

Points of Significance is an ongoing series of short articles about statistics in Nature Methods that started in 2013. Its aim is to provide clear explanations of essential concepts in statistics for a nonspecialist audience. The articles favor heuristic explanations and make extensive use of simulated examples and graphical explanations, while maintaining mathematical rigor.

Topics range from basic, but often misunderstood, such as uncertainty and P-values, to relatively advanced, but often neglected, such as the error-in-variables problem and the curse of dimensionality. More recent articles have focused on timely topics such as modeling of epidemics, machine learning, and neural networks.

In this article, we discuss the evolution of topics and details behind some of the story arcs, our approach to crafting statistical explanations and narratives, and our use of figures and numerical simulations as props for building understanding.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Crafting 10 Years of Statistics Explanations: Points of Significance. (read)

Altman, N. & Krzywinski, M. (2025) Crafting 10 Years of Statistics Explanations: Points of Significance. Annual Review of Statistics and Its Application 12:69–87.

Propensity score matching

Mon 16-09-2024

I don’t have good luck in the match points. —Rafael Nadal, Spanish tennis player

In many experimental designs, we need to keep in mind the possibility of confounding variables, which may give rise to bias in the estimate of the treatment effect.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Propensity score matching. (read)

If the control and experimental groups aren't matched (or, roughly, similar enough), this bias can arise.

Sometimes this can be dealt with by randomizing, which on average can balance this effect out. When randomization is not possible, propensity score matching is an excellent strategy to match control and experimental groups.

Kurz, C.F., Krzywinski, M. & Altman, N. (2024) Points of significance: Propensity score matching. Nat. Methods 21:1770–1772.

Understanding p-values and significance

Tue 24-09-2024

P-values combined with estimates of effect size are used to assess the importance of experimental results. However, their interpretation can be invalidated by selection bias when testing multiple hypotheses, fitting multiple models or even informally selecting results that seem interesting after observing the data.

We offer an introduction to principled uses of p-values (targeted at the non-specialist) and identify questionable practices to be avoided.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Understanding p-values and significance. (read)

Altman, N. & Krzywinski, M. (2024) Understanding p-values and significance. Laboratory Animals 58:443–446.

Depicting variability and uncertainty using intervals and error bars

Thu 05-09-2024

Variability is inherent in most biological systems due to differences among members of the population. Two types of variation are commonly observed in studies: differences among samples and the “error” in estimating a population parameter (e.g. mean) from a sample. While these concepts are fundamentally very different, the associated variation is often expressed using similar notation—an interval that represents a range of values with a lower and upper bound.

In this article we discuss how common intervals are used (and misused).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Depicting variability and uncertainty using intervals and error bars. (read)

Altman, N. & Krzywinski, M. (2024) Depicting variability and uncertainty using intervals and error bars. Laboratory Animals 58:453–456.

Nasa to send our human genome discs to the Moon

Sat 23-03-2024

We'd like to say a ‘cosmic hello’: mathematics, culture, palaeontology, art and science, and ... human genomes.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
SANCTUARY PROJECT | A cosmic hello of art, science, and genomes. (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
SANCTUARY PROJECT | Benoit Faiveley, founder of the Sanctuary project gives the Sanctuary disc a visual check at CEA LeQ Grenoble (image: Vincent Thomas). (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
SANCTUARY PROJECT | Sanctuary team examines the Life disc at INRIA Paris Saclay (image: Benedict Redgrove) (details)
Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA
Google whack “vicissitudinal corporealization”
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