The archive contains 1,710 quotes. From Dorothy Parker to Pinky and Brain, you're sure to find something special.
There are quote collections about love, heart, desire, life, death, god, mind, science.
Feeling lucky? Read 10 random quotes. Well, will you, punk?
A subset of random quotes
The fir trees dark and high;
I used to think their slender tops
Where close against the sky:
It was a childish ignorance,
But now ’tis little joy
To know I’m farther off from heav’n
Than when I was a boy.
That floats on high o’er vales and hills,
When all at once I saw a crowd,
A host of golden daffodils;
Beside the lake, beneath the trees.
Fluttering and dancing in the breeze.
and the presence of absence:
"My Novel" not found.
Certainly aged.
Should every creature drink but I,
Why, man of morals, tell me why?
Who first misuse, then cast their toys away.
on the shoulders of giants.
And men below, and saints above:
For love is heaven, and heaven is love.
Propensity score weighting
It is not certain that everything is uncertain. —Blaise Pascal
We have already explored how we can mitigate bias caused by confounding variables in observational studies using propensity score (PS) matching (PSM) and propensity score weighting (PSW). However, any statistical model is only as good as its assumptions and, if it is specified incorrectly, it can itself produce biased estimates of the treatment effect.
This month, we explore double robustness, a powerful statistical concept that provides a valuable “safety net” against the risk of an incorrect model. It offers two opportunities, instead of just one, to obtain a valid estimate of the treatment effect â making it possible to draw credible causal inferences from observational data without having to depend on a single set of modeling assumptions.
Kurz, C.F., Krzywinski, M. & Altman, N. (2026) Points of significance: Double Robustness. Nat. Methods 23:868–869.
Nature Biotechnology cover
My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.
Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.
Browse my gallery of cover designs.
Happy 2026 Ï Day—
Art for the 5%
Celebrate Ï Day (March 14th) and enjoy the art — but only if you're part of the 5%.
Go ahead, see what you can't see.
Ishihara's Tests for Colour Deficiency
Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.
I also provide the position, size, and color of each circle on each test plate.
Symmetric alternatives to the ordinary least squares regression
What immortal hand or eye, could frame thy fearful symmetry? — William Blake, "The Tyger"
This month, we look at symmetric regression, which, unlike simple linear regression, it is reversible â remaining unaltered when the variables are swapped.
Simple linear regression can summarize the linear relationship between two variables `X` and `Y` â for example, when `Y` is considered the response (dependent) and `X` the predictor (independent) variable.
However, there are times when we are not interested (or able) to distinguish between dependent and independent variables â either because they have the same importance or the same role. This is where symmetric regression can help.
Luca Greco, George Luta, Martin Krzywinski & Naomi Altman (2025) Points of significance: Symmetric alternatives to the ordinary least squares regression. Nat. Methods 22:1610–1612.