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A patient-centric research initiative, consisting of oncologists, pathologists and other clinical, research, and technical personnel, studying the impact of embedding whole genome and transcriptome analysis into the clinical care of B.C. patients with advanced cancers.
I have made art using data from this project, including art posters and the DNA on 10th wayfinding signs.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
1,709 quotes and all is well.

The archive contains 1,709 quotes. From Dorothy Parker to Pinky and Brain, you're sure to find something special.

There are quote collections about love, heart, desire, life, death, god, mind, science.

Feeling lucky? Read 10 random quotes. Well, will you, punk?

All quotes about god

13
Take not God’s name in vain: select a time when it will have effect.
Ambrose Bierce
48
I love thee with the love I seemed to lose
With my lost saints,—I love thee with the breath
Smiles, tears, of all my life!—and, if God choose,
I shall but love thee better after death.
Elizabeth Barrett Browning
Sonnets from the Portuguese
104
Poems are made by fools like me,
But only God can make a tree.
Joyce Kilmer
Trees
117
All are but parts of one stupendous whole,
Whose body Nature is, and God the soul.
Alexander Pope
Essay on Man, Epistle i. 267.
243
Conceit is God’s gift to little men.
298
Poems are made by fools like me,
But only God can make a tree.
Joyce Kilmer
Trees
370
Men rarely (if ever) manage to dream up a god superior to themselves. Most gods have the manners and morals of a spoiled child.
Lazarus Long
Time Enough for Love
414
And, while with silent, lifting mind I’ve trod
The high untrespassed sanctity of space,
Put out my hand, and touched the face of God.
John Gillespie Magee, Jr.
452
God must love stupid people, He made so many of them.
457
If it turns out that there is a God, I don’t think that he’s evil. But the worst that you can say about him is that basically he’s an underachiever.
Woody Allen
556
% ar m God
ar: God does not exist
561
God made the integers; all else is the work of Man.
Kronecker
591
If you believe in the light, it’s because of obscurity.
If you believe in happiness it’s because of unhappiness.
If you believe in God, then you have to believe in the Devil.
Father X
Church of Notre Dame, Paris
609
O God, if there be a God, save my soul, if I have a soul!
611
See the happy moron,
He doesn’t give a damn.
I wish I were a moron.
My God! Perhaps I am!
706
An Apology for the Devil: It must be remembered that we have only heard one side of the case. God has written
all the books.
Samuel Butler
Note Books
741
And almost every one when age,
Disease, or sorrows strike him,
Inclines to think there is a God,
Or something very like Him.
Arthur Hugh Clough
Dipsychus, sc. vi
783
So nigh is grandeur to our dust,
So near is God to man,
When Duty whispers low, Thou must,
The youth replies, I can.
Ralph Waldo Emerson
Voluntaries, iii
957
Gott ist tot: aber so wie die Art der Menschen ist, wird es vielleicht noch jahrtausendlang Hohlen geben, in denen man seinen Schatten zeigt.
[God is dead: but considering the state the species Man is in, there will perhaps be caves, for ages yet, in which his shadow will be shown.]
Friedrich Nietzsche
Ecce Homo
1082
O God! methinks it were a happy life,
To be no better than a homely swain;
To sit upon a hill, as I do now,
To carve out dials, quaintly, point by point,
Thereby to see the minutes how they run,
How many make the hour full complete;
How many hours bring about the day;
How many days will finish up the year;
How many years a mortal man may live.
William Shakespeare
Henry VII, Part III, II.v.21
1213
I loved you without hope, a mute offender;
What jealous pangs, what shy despairs I knew!
A love as deep as this, as true, as tender,
God grant another may yet offer you.
Alexander Pushkin
I Loved You Once
1218
I have heard the song of the blossoms and the old chant of the sea,
And seen strange lands from under the arched white sails of ships;
But the loveliest things of beauty God ever has showed to me,
Are her voice, and her hair, and eyes, and the dear red curve of her lips.
John Masefield
Beauty
1284
And this, O love, my pitiable plight
Whenever from my circling arms you stray;
This little world of mine has lost its light....
I hope to God, my dear, that you can say
The same to me.
Dorothy Parker
Rondeau Redouble
1333
How can I believe in God when just last week I got
my tongue caught in the roller of an electric typewriter?
Woody Allen
1334
Man is a god in ruins.
Ralph Waldo Emerson
1386
God made everything out of nothing, but the nothingness
shows through.
Paul Valery
1402
Which is it, is man one of God’s blunders or is
God one of man’s?
Friedrich Nietzsche
1416
Thank God men cannot as yet fly and lay waste the
sky as well as the earth!
Henry David Thoreau
1477
Nothing but blackness above
And nothing that moves but the cars...
God, if you wish for our love,
Fling us a handful of stars!
Louis Untermeyer
Caliban in the Coal Mines
1526
God is the immemorial refuge of the incompetent, the helpless, the miserable. They find not only sanctuary in His arms, but also a kind of superiority, soothing to their macerated egos; He will set them above their betters.
H.L. Mencken
1534
If the average man is made in God’s image, then a man such as Beethoven or Aristotle is plainly superior to God, and so God may be jealous of him, and eager to see his superiority perish with his bodily frame. All animal breeders know how difficult it is to maintain a fine strain. The universe seems to be in a conspiracy to encourage the endless reproduction of peasants and Socialists, but a subtle and mysterious opposition stands eternally against the reproduction of philosophers.
H.L. Mencken
In Defense of Women
1602
We turn toward God only to obtain the impossible.
Albert Camus
news + thoughts

How Analyzing Cosmic Nothing Might Explain Everything

Thu 18-01-2024

Huge empty areas of the universe called voids could help solve the greatest mysteries in the cosmos.

My graphic accompanying How Analyzing Cosmic Nothing Might Explain Everything in the January 2024 issue of Scientific American depicts the entire Universe in a two-page spread — full of nothing.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
How Analyzing Cosmic Nothing Might Explain Everything. Text by Michael Lemonick (editor), art direction by Jen Christiansen (Senior Graphics Editor), source: SDSS

The graphic uses the latest data from SDSS 12 and is an update to my Superclusters and Voids poster.

Michael Lemonick (editor) explains on the graphic:

“Regions of relatively empty space called cosmic voids are everywhere in the universe, and scientists believe studying their size, shape and spread across the cosmos could help them understand dark matter, dark energy and other big mysteries.

To use voids in this way, astronomers must map these regions in detail—a project that is just beginning.

Shown here are voids discovered by the Sloan Digital Sky Survey (SDSS), along with a selection of 16 previously named voids. Scientists expect voids to be evenly distributed throughout space—the lack of voids in some regions on the globe simply reflects SDSS’s sky coverage.”

voids

Sofia Contarini, Alice Pisani, Nico Hamaus, Federico Marulli Lauro Moscardini & Marco Baldi (2023) Cosmological Constraints from the BOSS DR12 Void Size Function Astrophysical Journal 953:46.

Nico Hamaus, Alice Pisani, Jin-Ah Choi, Guilhem Lavaux, Benjamin D. Wandelt & Jochen Weller (2020) Journal of Cosmology and Astroparticle Physics 2020:023.

Sloan Digital Sky Survey Data Release 12

constellation figures

Alan MacRobert (Sky & Telescope), Paulina Rowicka/Martin Krzywinski (revisions & Microscopium)

stars

Hoffleit & Warren Jr. (1991) The Bright Star Catalog, 5th Revised Edition (Preliminary Version).

cosmology

H0 = 67.4 km/(Mpc·s), Ωm = 0.315, Ωv = 0.685. Planck collaboration Planck 2018 results. VI. Cosmological parameters (2018).

Error in predictor variables

Tue 02-01-2024

It is the mark of an educated mind to rest satisfied with the degree of precision that the nature of the subject admits and not to seek exactness where only an approximation is possible. —Aristotle

In regression, the predictors are (typically) assumed to have known values that are measured without error.

Practically, however, predictors are often measured with error. This has a profound (but predictable) effect on the estimates of relationships among variables – the so-called “error in variables” problem.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Error in predictor variables. (read)

Error in measuring the predictors is often ignored. In this column, we discuss when ignoring this error is harmless and when it can lead to large bias that can leads us to miss important effects.

Altman, N. & Krzywinski, M. (2024) Points of significance: Error in predictor variables. Nat. Methods 20.

Background reading

Altman, N. & Krzywinski, M. (2015) Points of significance: Simple linear regression. Nat. Methods 12:999–1000.

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of significance: Logistic regression. Nat. Methods 13:541–542 (2016).

Das, K., Krzywinski, M. & Altman, N. (2019) Points of significance: Quantile regression. Nat. Methods 16:451–452.

Convolutional neural networks

Tue 02-01-2024

Nature uses only the longest threads to weave her patterns, so that each small piece of her fabric reveals the organization of the entire tapestry. – Richard Feynman

Following up on our Neural network primer column, this month we explore a different kind of network architecture: a convolutional network.

The convolutional network replaces the hidden layer of a fully connected network (FCN) with one or more filters (a kind of neuron that looks at the input within a narrow window).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Convolutional neural networks. (read)

Even through convolutional networks have far fewer neurons that an FCN, they can perform substantially better for certain kinds of problems, such as sequence motif detection.

Derry, A., Krzywinski, M & Altman, N. (2023) Points of significance: Convolutional neural networks. Nature Methods 20:1269–1270.

Background reading

Derry, A., Krzywinski, M. & Altman, N. (2023) Points of significance: Neural network primer. Nature Methods 20:165–167.

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of significance: Logistic regression. Nature Methods 13:541–542.

Neural network primer

Tue 10-01-2023

Nature is often hidden, sometimes overcome, seldom extinguished. —Francis Bacon

In the first of a series of columns about neural networks, we introduce them with an intuitive approach that draws from our discussion about logistic regression.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Neural network primer. (read)

Simple neural networks are just a chain of linear regressions. And, although neural network models can get very complicated, their essence can be understood in terms of relatively basic principles.

We show how neural network components (neurons) can be arranged in the network and discuss the ideas of hidden layers. Using a simple data set we show how even a 3-neuron neural network can already model relatively complicated data patterns.

Derry, A., Krzywinski, M & Altman, N. (2023) Points of significance: Neural network primer. Nature Methods 20:165–167.

Background reading

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of significance: Logistic regression. Nature Methods 13:541–542.

Cell Genomics cover

Mon 16-01-2023

Our cover on the 11 January 2023 Cell Genomics issue depicts the process of determining the parent-of-origin using differential methylation of alleles at imprinted regions (iDMRs) is imagined as a circuit.

Designed in collaboration with with Carlos Urzua.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Our Cell Genomics cover depicts parent-of-origin assignment as a circuit (volume 3, issue 1, 11 January 2023). (more)

Akbari, V. et al. Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq (2023) Cell Genomics 3(1).

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)
Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA
Google whack “vicissitudinal corporealization”
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