data visualization + celebration
Genome Sciences Center 20th Anniversary Clothing, Music, Drinks and Art
On 15 November 2019, the Genome Sciences Center held its 20th anniversary celebration.
Here you can read about the design of the evening's clothing, music, drinks and other art.
Biology is the only science in which multiplication means the same thing as division.
flow cells
Illumina flow cells
An 8-lane Illumina flow cell from Canada’s Michael Smith Genome Sciences Centre’s sequencing lab. Using a patterned array of billions of nanowells and sequencing-by-synthesis, this flow cell is capable of collecting up to 1,200,000,000,000 bases in reads of 150 bases from up to 8 independent samples in 73 hours.
PromethION flow cells
An Oxford Nanopore Technologies PromethION flow cell from Canada’s Michael Smith Genome Sciences Centre’s sequencing lab. Using protein nanopores embedded in a membrane, this flow cell is capable of sequencing up to 75,000,000,000 bases in read lengths ranging from 100 to 300,000 bases in 72 hours with high accuracy across repetitive regions of a genome. A PriomethION sequencer can process up to 24 flow cells in parallel.
MinION flow cells
An Oxford Nanopore Technologies MinION flow cell from Canada’s Michael Smith Genome Sciences Centre’s sequencing lab. Using protein nanopores embedded in a membrane, this flow cell is capable of sequencing up to 16,000,000,000 bases in read lengths ranging from 100 to 300,000 bases in 72 hours. Able to accurately sequence across repetitive regions of a genome, this MinION sequencer can fit in the palm of your hand and runs over USB.
engineering drawings of flow cell mounts
Propensity score weighting
It is not certain that everything is uncertain. —Blaise Pascal
We have already explored how we can mitigate bias caused by confounding variables in observational studies using propensity score (PS) matching (PSM) and propensity score weighting (PSW). However, any statistical model is only as good as its assumptions and, if it is specified incorrectly, it can itself produce biased estimates of the treatment effect.
This month, we explore double robustness, a powerful statistical concept that provides a valuable “safety net” against the risk of an incorrect model. It offers two opportunities, instead of just one, to obtain a valid estimate of the treatment effect — making it possible to draw credible causal inferences from observational data without having to depend on a single set of modeling assumptions.
Kurz, C.F., Krzywinski, M. & Altman, N. (2026) Points of significance: Double Robustness. Nat. Methods 23:868–869.
Nature Biotechnology cover
My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.
Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.
Browse my gallery of cover designs.
Happy 2026 π Day—
Art for the 5%
Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.
Go ahead, see what you can't see.
Ishihara's Tests for Colour Deficiency
Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.
I also provide the position, size, and color of each circle on each test plate.
Symmetric alternatives to the ordinary least squares regression
What immortal hand or eye, could frame thy fearful symmetry? — William Blake, "The Tyger"
This month, we look at symmetric regression, which, unlike simple linear regression, it is reversible — remaining unaltered when the variables are swapped.
Simple linear regression can summarize the linear relationship between two variables `X` and `Y` — for example, when `Y` is considered the response (dependent) and `X` the predictor (independent) variable.
However, there are times when we are not interested (or able) to distinguish between dependent and independent variables — either because they have the same importance or the same role. This is where symmetric regression can help.
Luca Greco, George Luta, Martin Krzywinski & Naomi Altman (2025) Points of significance: Symmetric alternatives to the ordinary least squares regression. Nat. Methods 22:1610–1612.
Beyond Belief Campaign BRCA Art
Fuelled by philanthropy, findings into the workings of BRCA1 and BRCA2 genes have led to groundbreaking research and lifesaving innovations to care for families facing cancer.
This set of 100 one-of-a-kind prints explore the structure of these genes. Each artwork is unique — if you put them all together, you get the full sequence of the BRCA1 and BRCA2 proteins.
