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data visualization + art
There are some new shapes on the streets of Vancouver. Genomic sequence decoded from patients are shown as a puzzle — can you solve the mystery of the cell?

Gene Cultures — MIT Museum Exhibit

Scale and structure of the human genome

1 · The MIT museum reopens

The MIT Museum reopens at its new location on 2nd October 2022.

My art appears in the new Gene Cultures exhibit.

2 · Gene Cultures Exhibit

As the pace of technological advances in the field of genetic discovery quickens, questions arise.

Who decides how and when transformative new biotechnologies will be used? What questions do we need to ask before making decisions leading to irrevocable results?

Join the conversation as you explore dramatic breakthroughs in genetic technologies and engage with artworks — wiitty, provocative, absurd, and profound — that prompt us to consider our future — now.

The Gene Cultures exhibit is Located in the Henri A. Termeer Gallery

Text by MIT museum

3 · My art at the genome exibit

Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The plaque explaining the projection that shows the scale of structures in the human genome.

To find my exhibit, look for the pink chicken. You can't miss it.

Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The animated projection is on a large wall at the entrance to the exhibit. Right next to the pink chicken. (photo Martin Krzywinski)
Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The animated projection is on a large wall at the entrance to the exhibit. Right next to the pink chicken. (photo Anna Olivella)

3.1 · Animation sequence

Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The opening sequence cycles through the layers to be explained.
Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The genome is big. We count up to 3,088,269,832 bases, which is the total length of chromosomes 1–22,X,Y in the hg38 human genome assembly.
Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The contents of the genome are grouped into chromosomes.
Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The bands reflect density of chromatin packing.
Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
About 20,000 genes represent the key functional components.
Gene Cultures exhibit at the MIT Museum - Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Genes (and the proteins that the encode) are key targets for therapies.

The size and position of elements in the animation is based on the hg38 assembly, which is (as of 2022) the canonical reference.

The very latest human genome assembly (CHM13v2 telomere-to-telomere) has 3,117,275,501 bases.

4 · Credits

concept and art direction
Exhibit developer (Life Sciences)
concept & design
Martin Krzywinski
Staff Scientist
Canada's Michael Smith Genome Sciences Centre
creative lead
Kim Gim
motion designer
Devon Burgoyne
designer
An Bui
content strategist
Ksenia Dynkin
Canada's Michael Smith Genome Sciences Centre (GSC) at PHSA is an international leader in genomics, proteomics and bioinformatics for precision medicine. By developing and deploying cutting-edge genome sequencing, computational and analytical technology, we are creating novel strategies to prevent and diagnose cancers and other diseases, uncovering new therapeutic targets and helping the world realize the social and economic benefits of genome science.
We are the Canadian node of the Earth Biogenome Project.
news + thoughts

Nature Biotechnology cover

Thu 23-04-2026

My cover design on the 7 April 2026 Nature Biotechnology issue shows the dendrogram that represents a cluster of uniquely expressed (or downregulated) genes in human naive stem cells induced from such cells. Within each dendrogram block, the genomic barcode sequence (sampled from Supplementary Table 1) is depicted with a Code 39 barcode. The highlighted barcode is one of those used for cell isolation.

Ishiguro S. et al. A multi-kingdom genetic barcoding system for precise clone isolation (2026) Nature Biotechnology 44:616–629.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Nature Biotechnology phylogenetic tree cover (volume 44, issue 4, 7 April 2026). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Happy 2026 π Day—
Art for the 5%

Fri 13-03-2026

Celebrate π Day (March 14th) and enjoy the art — but only if you're part of the 5%.

Go ahead, see what you can't see.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2026 π DAY | Art for the 5%. Shown in the style of Ishihara color test plates, the art is visible only to those with colour blindness. (details)

Ishihara's Tests for Colour Deficiency

Sun 08-03-2026

Authentic and accurate images of Ishihara's test plates photographed (and lovingly color-corrected) from the 38-plate Ishihara's Tests for Colour Deficiency.

I also provide the position, size, and color of each circle on each test plate.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
ISHIHARA'S TEST PLATE 6 | This plate is part of the set of transformation plates. If you see 5, you're ok. If you see 2, you're not. (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
ISHIHARA'S TEST PLATE 18 | This plate is part of the set of mysterious hidden plates. If you don't see anything, you're ok. If you see 5, you're not. (details)

Symmetric alternatives to the ordinary least squares regression

Wed 23-07-2025

What immortal hand or eye, could frame thy fearful symmetry? — William Blake, "The Tyger"

This month, we look at symmetric regression, which, unlike simple linear regression, it is reversible — remaining unaltered when the variables are swapped.

Simple linear regression can summarize the linear relationship between two variables `X` and `Y` — for example, when `Y` is considered the response (dependent) and `X` the predictor (independent) variable.

However, there are times when we are not interested (or able) to distinguish between dependent and independent variables — either because they have the same importance or the same role. This is where symmetric regression can help.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Symmetric alternatives to the ordinary least squares regression. Geometry of quantities minimized in OLS and symmetric regression. OLS minimizes `\Sigma e_y^2` in `Y` ~ `X` and `\Sigma e_x^2` `X` ~ `Y`. Pythagorean regression minimizes AB (magenta). Geometric means regression (GMR) minimizes area of ABP (orange). Orthogonal regression (OR) minimizes HP (blue). (read)

Luca Greco, George Luta, Martin Krzywinski & Naomi Altman (2025) Points of significance: Symmetric alternatives to the ordinary least squares regression. Nat. Methods 22:1610–1612.

Beyond Belief Campaign BRCA Art

Wed 11-06-2025

Fuelled by philanthropy, findings into the workings of BRCA1 and BRCA2 genes have led to groundbreaking research and lifesaving innovations to care for families facing cancer.

This set of 100 one-of-a-kind prints explore the structure of these genes. Each artwork is unique — if you put them all together, you get the full sequence of the BRCA1 and BRCA2 proteins.

Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentrePHSA
Google whack “vicissitudinal corporealization”
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